In cancer surgery, the single most important predictor of local recurrence is the tissue margins.1,2 Other methods used to label tissue margins on the specimen x-ray, such as metal tags, can cause error by obstructing the view of the lesion and creating shadows on the image. This may lead to error or delay.
Vector Surgical's Tissue Orientation System, consisting of the MarginMarker® sterile ink kit and CorrectClips® radiographic markers, provides secure and accurate designation of specimen margins, potentially resulting in more accurate re-excisions,3 fewer unnecessary re-excisions,3,4 lower cancer recurrencexcisions,1,5,6 and improved cosmesis3
Radiology receives images on which the specimen is fully visible and margins are labeled with CorrectClips to indicate the orientation. The tissue is displayed without obstruction or confounding elements that can otherwise cause error or delay.
1. Gage, I.; Schnitt, S.J.; Nixon, A.J.; Silver, B.; Recht, A.; Troyan, S.L.; Eberlein, T.; Love, S.M.; Gelman, R.; Harris, J.R.; and Connolly, J.L. “Pathologic Margin Involvement and the Risk of Recurrence in Patients Treated with Breast-Conserving Therapy.” Cancer 78.9 (1996): 1921-1928.
2. MacDonald, H.R.; Silverstein, M.J.; Mabry, H.; Moorthy, B.; Ye, W.; Epstein, M.S.; Holmes, D.; Silberman, H.; and Lagios, M. “Local Control in Ductal Carcinoma In Situ Treated by Excision Alone: Incremental Benefit of Larger Margins.” American Journal of Surgery 190.4 (2005): 521-525.
3. Landercasper, J., Attai, D., Atisha, D., Beitsch, P., Bosserman, L., Boughey, J., Carter, J., Edge, S., Feldman, S., Froman, J. and Greenberg, C. "Toolbox to reduce lumpectomy reoperations and improve cosmetic outcome in breast cancer patients: The American Society of Breast Surgeons Consensus Conference." Annals of Surgical Oncology 22.10 (2015): 3174-3183.
4. Dooley, W.C. and Parker, J. “Understanding the Mechanisms Creating False Positive Lumpectomy Margins.” American Journal of Surgery 190 (2005): 606-608.
5. Lovrics, P.J.; Cornacchi, S. D.; Farrokhyar, F.; Garnett, A.; Chen, V.; Franic, S.; and Simunovic, M. “The Relationship Between Surgical Factors and Margin Status After Breast-Conservation Surgery for Early Stage Breast Cancer.” The American Journal of Surgery (2009): 197, 740-746.
6. Menes, T.S.; Tartter, P.I.; Bleiweiss, I.; Godbold, J.H.; Estabrook, A.; and Smith, S.R. “The Consequence of Multiple Re-excisions to Obtain Clear Lumpectomy Margins in Breast Cancer Patients.” Annals of Surgical Oncology 12.11 (2005): 881-885.
7. Rebner, M; Pennes, D.R.; Baker, D.E.; Adler, D.D.; and Boyd, P. “Two-View Specimen Radiography in Surgical Biopsy of Nonpalpable Breast Masses.” American Journal of Roentgenology 149 (1987): 283-285.
8. Britton, P.D.; Sonoda, L.I.; Yamamoto, A.K.; Koo, B.; Soh, E.; and Goud, A. “Breast Surgical Specimen Radiographs: How Reliable Are They?” European Journal of Radiology 79 (2011): 245-249.
9. Wong, J.W.; Bai, H.; Abdul-Karim, F.W.; and MacLennan, G.T. “Simulation of Microcalcifications on Specimen Radiographs of Breast Biopsies by Inks Used in Marking the Surgical Resection Margins.”, The Breast Journal10.5 (2004): 423-426.