The MarginMarker histology marking dyes provide greater certainty that the designated margin for re-excision is correct.
The MarginMarker histology marking dyes provide greater certainty that the designated margin for re-excision is correct.   Surgeons use the MarginMarker tissue ink kit to mark margins of excised tissue while in the operating room. Our tissue margin marking dyes completely define each margin plane, so that the pathology lab receives a clearly marked specimen.

The New Standard for Tissue Orientation®

In the quest to provide the best possible care for cancer patients, leading hospitals and physicians are eliminating error and improving patient outcomes by using Vector Surgical's MarginMarker. Surgeons use the MarginMarker sterile ink kit to define margins of excised tissue while in the OR; the pathology lab receives a clearly marked specimen. Unlike suture or metal tags, MarginMarker inks completely define each margin plane, resulting in more accurate re-excisions and potentially lower cancer recurrence.

MarginMarker is one component of the Vector Surgical Tissue Orientation System, which includes MarginMarker sterile tissue dyes for pathology analysis and CorrectClips translucent radiographic markers used to orient excised tissue on the intraoperative image.



MarginMarker sterile inks fully define each margin surface, providing more secure and accurate designation of tissue margins. Use of MarginMarker can result in:

Better Patient Outcomes

  • More accurate re-excisions1,2
  • Fewer unnecessary re-excisions1,3,4
  • Potentially lower cancer recurrence when complete resection is accomplished5,6
  • Better cosmesis due to re-excision of less tissue2,4

Valuable Time Saved

  • More efficient surgeon-pathologist communication

Improved Safety

  • Less risk of needle stick in the OR

MarginMarker Sterile Ink Kit

  • The MarginMarker sterile ink kit is a sterile, single use device. The kit includes six ink colors, applicators, fixative, and annotation labels.


Performance of MarginMarker Inks

  • Formulated to secure to tissue, allowing precise and quick application in the OR
  • Adhere throughout specimen processing, including after suspension in formalin
  • Sterility supports cytogenetic analysis or microbiology testing
  • Minimize the risk of cross contamination with multiple specimens



Cancer surgeries in which tissue orientation is important, including:

  • General and Oncological Surgeons: Breast, pancreas, colon, liver, lip, anus, ovary, uterus, labia and soft tissue
  • Plastic, ENT and Dermatological Surgeons: Basal skin cancer, squamous cell carcinoma and melanoma



1. Singh, M.; Singh, G.; Hogan, K.T.; Atkins, K.A.; and Schroen, A.T. “The Effect of Intraoperative Specimen Inking on Lumpectomy Re-excision Rates.” World Journal of Surgical Oncology 8.4 (2010).

2. Gibson, G.R.; Lesnikoski, B.A.; Yoo, J.; Mott, L.A.; Cady, B.; and Barth, R.J. Jr. “A Comparison of Ink-Directed and Traditional Whole-Cavity Re-Excision for Breast Lumpectomy Specimens with Positive Margins.” Annals of Surgical Oncology 8.9 (2001): 693-704.

3. Dooley, W.C. and Parker, J. “Understanding the Mechanisms Creating False Positive Lumpectomy Margins.” American Journal of Surgery 190 (2005): 606-608.

4. Landercasper, J., Attai, D., Atisha, D., Beitsch, P., Bosserman, L., Boughey, J., Carter, J., Edge, S., Feldman, S., Froman, J. and Greenberg, C. "Toolbox to reduce lumpectomy reoperations and improve cosmetic outcome in breast cancer patients: The American Society of Breast Surgeons Consensus Conference." Annals of Surgical Oncology 22.10 (2015): 3174-3183.

5. Gage, I.; Schnitt, S.J.; Nixon, A.J.; Silver, B.; Recht, A.; Troyan, S.L.; Eberlein, T.; Love, S.M.; Gelman, R.; Harris, J.R.; and Connolly, J.L. “Pathologic Margin Involvement and the Risk of Recurrence in Patients Treated with Breast-Conserving Therapy.” Cancer 78.9 (1996): 1921-1928.

6. Menes, T.S.; Tartter, P.I.; Bleiweiss, I.; Godbold, J.H.; Estabrook, A.; and Smith, S.R. “The Consequence of Multiple Re-excisions to Obtain Clear Lumpectomy Margins in Breast Cancer Patients.” Annals of Surgical Oncology 12.11 (2005): 881-885.


Additional Medical References