MarginMarker sterile inks fully define each margin surface, providing more secure and accurate designation of tissue margins. Use of MarginMarker can result in:
Better Patient Outcomes
- More accurate re-excisions1,2
- Fewer unnecessary re-excisions1,3,4
- Potentially lower cancer recurrence when complete resection is accomplished5,6
- Better cosmesis due to re-excision of less tissue2,4
Valuable Time Saved
- More efficient surgeon-pathologist communication
- Less risk of needle stick in the OR
MarginMarker Sterile Ink Kit
- The MarginMarker sterile ink kit is a sterile, single use device. The kit includes six ink colors, applicators, fixative, and annotation labels.
Performance of MarginMarker Inks
- Formulated to secure to tissue, allowing precise and quick application in the OR
- Adhere throughout specimen processing, including after suspension in formalin
- Sterility supports cytogenetic analysis or microbiology testing
- Minimize the risk of cross contamination with multiple specimens
Cancer surgeries in which tissue orientation is important, including:
- General and Oncological Surgeons: Breast, pancreas, colon, liver, lip, anus, ovary, uterus, labia and soft tissue
- Plastic, ENT and Dermatological Surgeons: Basal skin cancer, squamous cell carcinoma and melanoma
1. Singh, M.; Singh, G.; Hogan, K.T.; Atkins, K.A.; and Schroen, A.T. “The Effect of Intraoperative Specimen Inking on Lumpectomy Re-excision Rates.” World Journal of Surgical Oncology 8.4 (2010).
2. Gibson, G.R.; Lesnikoski, B.A.; Yoo, J.; Mott, L.A.; Cady, B.; and Barth, R.J. Jr. “A Comparison of Ink-Directed and Traditional Whole-Cavity Re-Excision for Breast Lumpectomy Specimens with Positive Margins.” Annals of Surgical Oncology 8.9 (2001): 693-704.
3. Dooley, W.C. and Parker, J. “Understanding the Mechanisms Creating False Positive Lumpectomy Margins.” American Journal of Surgery 190 (2005): 606-608.
4. Landercasper, J., Attai, D., Atisha, D., Beitsch, P., Bosserman, L., Boughey, J., Carter, J., Edge, S., Feldman, S., Froman, J. and Greenberg, C. "Toolbox to reduce lumpectomy reoperations and improve cosmetic outcome in breast cancer patients: The American Society of Breast Surgeons Consensus Conference." Annals of Surgical Oncology 22.10 (2015): 3174-3183.
5. Gage, I.; Schnitt, S.J.; Nixon, A.J.; Silver, B.; Recht, A.; Troyan, S.L.; Eberlein, T.; Love, S.M.; Gelman, R.; Harris, J.R.; and Connolly, J.L. “Pathologic Margin Involvement and the Risk of Recurrence in Patients Treated with Breast-Conserving Therapy.” Cancer 78.9 (1996): 1921-1928.
6. Menes, T.S.; Tartter, P.I.; Bleiweiss, I.; Godbold, J.H.; Estabrook, A.; and Smith, S.R. “The Consequence of Multiple Re-excisions to Obtain Clear Lumpectomy Margins in Breast Cancer Patients.” Annals of Surgical Oncology 12.11 (2005): 881-885.
Additional Medical References